Occurrence of stress, anxiety within the working of nurses could have a significant impact on the well-being of them. The term relaxation response on the other hand refers to the technique of dealing with stress which also contributes as the authentic way for turning off fight or flight response and thereby reduce the stress levels within the body bringing it back into the pre-stress level. The sole purpose of this study is to present a critical review of a quantitative study along with analyzing research design adopted by the researcher. The following research has focused on presenting a deep-intervening discussion on the The Effects of the Relaxation Response on Nurses’ Level of Anxiety, Depression, Well-Being, Work-Related Stress, and Confidence to Teach Patient.